Recently, Chengdu Cosmo Biotech Co., Ltd. received the official Human Repeat Insult Patch Test (HRIPT) report for its VeSpicule Silica 99% from Intertek, a globally recognized independent testing and certification organization. The six-week human clinical study demonstrated that VeSpicule Silica 99% exhibits an excellent skin safety profile, with no evidence of irritation or contact sensitization, providing authoritative safety validation for its application in cosmetics and personal care formulations.
High-Standard Human Testing with Rigorous Safety Evaluation
The study was conducted in strict accordance with the standard Human Repeat Insult Patch Test (HRIPT) protocol. A total of 50 healthy Chinese volunteers aged 18–65 years participated in the trial, which was conducted from March 9 to April 17, 2026.
Scientifically Designed Test and Control Groups
The test material consisted of VeSpicule Silica 99% formulated in petrolatum. To ensure scientific validity and reliable comparison, petrolatum was used as the negative control and a 0.3% SDS aqueous solution served as the positive control.
Multi-Phase Testing Procedure
The HRIPT study consisted of two key phases:
- Induction Phase: A three-week period involving nine consecutive patch applications.
- Challenge Phase: A final challenge patch application conducted 14–17 days after completion of the induction phase.
Throughout the study, skin responses were evaluated and documented at multiple time points by qualified dermatological professionals using standardized assessment criteria.
Diverse Participant Profile Enhancing Result Reliability
The participant group represented the primary skincare consumer population, ranging from 25 to 59 years of age. Subjects included individuals with Fitzpatrick-Pathak Skin Phototypes II, III, and IV, covering a broad range of skin tones and skin sensitivities. This diversity supports the applicability of the safety findings across a wide consumer demographic.
Key Findings: Zero Sensitization Throughout the Entire Study
During the complete six-week testing period, none of the 50 participants exhibited any signs of adverse skin reactions, including erythema, itching, swelling, or other indicators of sensitization.
The Intertek report concluded that VeSpicule Silica 99% demonstrates excellent skin compatibility, presents no skin irritation potential, and shows no evidence of contact sensitization under the conditions of the study. These findings confirm its suitability for use in gentle skincare formulations.
VeSpicule Silica 99%: Cosmo’s New Generation Functional Silica Ingredient
VeSpicule Silica 99% is a newly developed, high-purity needle-shaped silica ingredient introduced by Cosmo Biotech as part of its next-generation functional material portfolio.
The successful completion of Intertek’s stringent human safety assessment further strengthens the product’s scientific validation and safety credentials. VeSpicule Silica 99% can be reliably incorporated into a wide range of cosmetic and personal care formulations, including facial masks, serums, and body care products, supporting innovative applications in transdermal skincare delivery and gentle skin-renewal solutions.
Cosmo Biotech: A 14-Year Industry Pioneer in Sponge Spicule Technology
Chengdu Cosmo Biotech Co., Ltd. is a leading manufacturer and innovator in the hydrolyzed sponge (sponge spicule) industry and is widely recognized as a hidden champion in the global market.
For over 14 years, the company has focused on the research, production, and process optimization of functional ingredients designed to enhance transdermal absorption. Guided by its philosophy of “Dedication, Excellence, Industry Leadership, and Professional Achievement,” Cosmo Biotech has established a strong reputation through consistent product quality, comprehensive testing capabilities, and continuous innovation.
Today, Cosmo Biotech continues to provide global beauty and skincare brands with safe, effective, and scientifically validated functional ingredients, helping drive the next generation of skincare innovation.
